Waters SYNAPT G2-S HDMS Mass Spectrometer

SKU: 3346410

$110,000.00

1 in stock

Description

SYNAPT G2-S HDMS is a high resolution exact mass MS/MS platform designed to get you to the right result, faster – no matter how challenging your application is. When you want to reach beyond the boundaries of conventional mass spectrometry, SYNAPT G2-S High Definition Mass Spectrometry™ (HDMS™) provides a new dimension to your discovery capability by combining high efficiency ion mobility based measurements and separations with high performance tandem mass spectrometry. By enabling you to differentiate samples by size, shape, and charge – as well as mass – this unique capability allows you to make discoveries that simply aren’t possible any other way.

Warranty covers basic power-on functionality. Installation and validation not included in sales price but will need to be completed before accuracy can be confirmed. Please inquire about validation options that can expand warranty coverage, for additional cost.

Includes: 

  • Edwards XDS 46i Scroll Pump
  • Edwards XDS 100b Scroll Pump

 Manufacture Specification 

The SYNAPT G2-S HDMS System can operate in two modes:

 (a) TOF mode 

(b) Mobility-TOF mode

TOF Mass Resolution in Positive Ion:

  (a) Sensitivity Mode 10,000 FWHM measured on the (M + 6H)6+ isotope cluster from bovine insulin (m/z 956)  

 (b) Resolution Mode 20,000 FWHM measured on the (M + 6H)6+ isotope cluster from bovine insulin (m/z 956)  

 (c) High Resolution Mode 40,000 FWHM measured on the (M + 6H)6+ isotope cluster from bovine insulin (m/z 956)

TOF Mass Resolution in Negative Ion:

(a) Sensitivity Mode 10,000 FWHM measured on the (M – 4H)4- isotope cluster from bovine insulin (m/z 1431)  

 (b) Resolution Mode 20,000 FWHM measured on the (M – 4H)4- isotope cluster from bovine insulin (m/z 1431)  

 (c) High Resolution Mode 40,000 FWHM measured on the (M – 4H)4- isotope cluster from bovine insulin (m/z 1431)

Positive Ion MS Sensitivity:

 (a) Sensitivity Mode The peak at m/z 556 from a solution of 50 pg/μL leucine enkephalin in 50/50 acetonitrile/water  + 0.1% formic acid, infused at a flow rate of 5 μL/min, will have an intensity of greater than  41,600 ions per second. The instrument will be tuned to 10,000 resolution (as demonstrated on bovine insulin) and the mass range will be set to a maximum of 1200 m/z.  

(b) Resolution Mode The peak at m/z 556 from a solution of 50 pg/μL leucine enkephalin in 50/50 acetonitrile/water + 0.1% formic acid, infused at a flow rate of 5 μL/min, will have an intensity of greater than  20,800 ions per second. The instrument will be tuned to 20,000 resolution (as demonstrated on bovine insulin) and the mass range will be set to a maximum of 1200 m/z.

 (c) Enhanced Duty Cycle (EDC) Mode The peak at m/z 556 from a solution of 10 pg/μL leucine enkephalin in 50/50 acetonitrile/water  + 0.1% formic acid, infused at a flow rate of 5 μL/min, will have an intensity of greater than  24,800 ions per second. The instrument will be tuned to 20,000 resolution (as demonstrated on bovine insulin), with sensitivity set to a maximum at 556 m/z.

Positive Ion MS/MS Sensitivity:

  • Sensitivity Mode Using a [Glu1] -Fibrinopeptide B solution of 100 fmol/μL, at a flow rate of 5 μL/min and with the instrument tuned for 10,000 resolution (as demonstrated on bovine insulin), the intensity of the  most intense y” sequence ion from the MS/MS spectrum of the doubly charged precursor ion  (785.8 m/z) will be greater than 3,200 ions per second. The instrument mass range will be set to a maximum of 2000 m/z.

 

  • Resolution Mode Using a [Glu1] -Fibrinopeptide B solution of 100 fmol/μL, at a flow rate of 5μL/min and with the instrument tuned for 20,000 resolution (as demonstrated on bovine insulin), the intensity of  the most intense y” sequence ion from the MS/MS spectrum of the doubly charged precursor ion  (785.8 m/z) will be greater than 1,600 ions per second. The instrument mass range will be set to a maximum of 2000 m/z.

 

Negative Ion MS/MS Sensitivity:

 (a) Sensitivity Mode Using a solution of 500 pg/μL raffinose in 70/30 acetonitrile/water, at a flow rate of 5 μL/min and with the instrument tuned for 10,000 resolution (as demonstrated on bovine insulin), the intensity  of the fragment ion at 179.1 m/z in the MS/MS spectrum of the precursor ion at  503.2 m/z will be greater than 3,200 ions per second. The instrument mass range will be set to a maximum of 1200 m/z.

(b) Resolution Mode Using a solution of 500 pg/μL raffinose in 70/30 acetonitrile/water, at a flow rate of 5 μL/min and with the instrument tuned for 20,000 resolution (as demonstrated on bovine insulin), the intensity  of the fragment ion at 179.1 m/z in the MS/MS spectrum of the precursor ion at 503.2 m/z will be greater than 1,600 ions per second. The instrument mass range will be set to 1200 m/z.

 

Mass Scale Calibration Accuracy:

 The mass measurement accuracy of the instrument in High Resolution mode, using internal lock masses, is such that the RMS error between the measured and the accepted masses of peaks which have sufficient intensity, and are free from interference from other masses, will be less than 1 ppm over the range 150 to 900 m/z.

Mass Measurement Accuracy:

 The mass measurement accuracy of the instrument, in High Resolution mode, will be better than  1 ppm RMS, based on 10 consecutive repeat measurements of the [M + Na]+ ion of raffinose  (m/z 527.1588), using the [M + H]+ ions of leucine enkephalin (m/z 556.2771) and  4-acetamidophenol (m/z 152.0712) as the LockSpray lockmasses. Analyte and lockmass peaks must have sufficient intensity and be free of interference from other masses.

Mass Range:

 The TOF mass range is 20 to 100,000 m/z in Resolution mode, and 20 to 32,000 m/z in High Resolution mode. The m/z transmission range for a quadrupole in non-resolving mode is 20 to  16,000 m/z for a 4000 m/z quadrupole, and 20 to 32,000 m/z for an 8000 m/z quadrupole.

 

Edwards XDS 46i Scroll Pump 

Displacement 50 or 60Hz 60 m3h-1 / 35 ft3min-1
Peak pumping speed 50 or 60Hz 40 m3h-1 / 23.5 ft3min-1
Ultimate vacuum (Total pressure) 5 x 10-2 mbar / 4 x 10-2 Torr
Max continuous inlet pressure 40 mbar / 30 Torr
Max continuous outlet pressure 0.2 bar gauge / 2.9 psig
Max allowed inlet and GB pressure 0.5 bar gauge / 7 psig
Motor power 0.52kW
Power connector IEC EN60320 C19
Nominal rotation speed 1750 rpm
Weight 48 kg / 105 lb
Inlet flange NW40
Exhaust flange NW25
Noise level 55.4 dB (A)
Vibration <4.5mms -1 (rms)
Leak tightness (static) <1 x 10-6 mbar ls-1
Operating temperature range 10 to 40 °C / 50 to 104 °F

Edwards XDS 100b Scroll Pump 

Continous Inlet Pressure: 20 mbar
Pumping Speed 95 m3/h
Inlet Flange: NW 40
Exhaust Flange: NW 40
Weight: 48 kg / 105 lbs

Additional information

Weight 850 lbs
Dimensions 68 × 39 × 69 in
Make Waters
Model Synapt G2-S HDMS
Serial UEA018
Working Working
Item Condition Used
Includes ALL cables (power and data)|Computer with Software
Warranty 30-Day Warranty, 100% Parts and Labor
Voltage 240V
hertz 50Hz/60Hz

Reviews

★ ★ ★ ★ ★
"ANDbio has been a great partner for our used equipment needs and always provide timely updates of new arrivals of consigned equipment." - Phil
★ ★ ★ ★ ★
"Great company to work with. Tammy completed our first international equipment shipment with ease." - Fred
★ ★ ★ ★ ★
"Fast response, open to adjusting schedule as needed, and great customer interaction." - George